The aim of this project is to deepen our understanding in peptide crystallisation processes, while identifying scalable methodologies tailored for the crystallisation of emerging therapeutic modalities. Specific objectives:
1-Investigate the crystallisability of different fragments of model peptides by high-throughput (HT) screening.
2-Intermediate scale up (100mg-1g scale) of selected crystallisation conditions and initial evaluation as potential industrial processes.
3-Develop efficient in-silico virtual screening tools based on quantum chemical methods alongside experimental HT methodologies to accurately determine and predict industrially relevant properties of peptide crystals (e.g., solubility, structure, stability…).
4-Scale up selected crystallisation conditions to >10g using advanced PAT. Additionally, downstream processes, including filtration, washing, and drying, will also be investigated. 5-Employ advanced crystallisation kinetic process models using population/material balances to understand and describe peptide crystal growth and nucleation mechanisms, and for process control.
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